PHM141H1: Pharmaceutics


Achieving effective treatment of a disease while minimizing adverse effects of a drug requires rational selection, formulation and administration of an appropriate dosage form. This course teaches the scientific background and technical aspects important in dosage form design, basic dosage forms and their therapeutic applications. This course will focus on the biopharmaceutical considerations and physicochemical foundation of various dosage forms. Discussion will include preformulation factors (melting point, solubility, viscosity, dissolution, particle and solid state properties), rheology, pharmaceutical solutions, pharmaceutical powders, colloids and dispersions, complexation, chelation, and protein binding.