Antimicrobial Stewardship is an inter-disciplinary, multi-faceted approach to optimize antimicrobial use. While the ultimate goal of Antimicrobial Stewardship is to improve patient outcome, appropriate and effective use of antimicrobials is an important component to control antimicrobial resistance, minimize unintended consequences such as C. difficile infections, and to contain health care costs. As of 2013, presence of an active Antimicrobial Stewardship Program has been made a Required Operating Practice for acute care hospitals and long-term care facilities by Accreditation Canada. This course expands and deepens knowledge gained from the Year 2 Infectious Diseases Pharmacotherapy and Microbiology courses, with an emphasis on clinical application within the antimicrobial stewardship context. It will introduce students to the principles of antimicrobial stewardship to facilitate rational selection of antimicrobial regimens; stewardship interventions; quality improvement methods; as well as program development, implementation and evaluation. The course culminates to a team proposal presentation for an antimicrobial stewardship program based on a fictitious institution’s profile. Each team is tasked with convincing a panel of judges, who in practice are antimicrobial stewardship clinicians or program executives, to support their proposed program.